Beilstein J. Org. Chem.2020,16, 2929–2936, doi:10.3762/bjoc.16.242
that the C-(hetero)aryl-α-(arylamino)acetonitrile derivatives can be considered genotoxically safe and possibly antimutagenic.
Keywords: Amestest; α-aminoacetonitriles; ferrocene; phenothiazine; SEM; single crystal XRD; sonochemistry; Introduction
Sonochemistry can be considered as a major
, ferrocene or benzene units was screened by the Salmonella mutagenicity assay (Amestest) [28] using S. typhimurium TA98 and TA100 strains.
Results and Discussions
Ultrasound-assisted synthesis
The Strecker reaction between (hetero)aromatic aldimines and TMSCN in poly(ethylene glycol) (PEG)–water medium [18
-recognized Amestest to screen the mutagenic potential for three selected C-substituted α-aminoacetonitriles comprising different hetero(aromatic) units: phenothiazinyl (2c), ferrocenyl (2i), and phenyl (2l), respectively. The similarity of the tested aminoacetonitrile series was set aside by the N
Beilstein J. Org. Chem.2016,12, 1434–1439, doi:10.3762/bjoc.12.138
using two different techniques: The Vibrio harveyi luminescence assay and the Amestest. The obtained results support previous findings contesting QAS safety and indicate that QAS, specifically pyridinium derivatives, might be mutagenic.
Keywords: 6-bromohexyl D-glucopyranoside; microbiological
activity using the Salmonella typhimurium TA98 strain in the Amestest. The Amestest is a well-established and routinely used bacterial mutagenicity assay for examining the safety of newly obtained compounds before they are commercially available.
In this work, five out of eight tested QASs, namely, 4b
positive control (C2) was considered 100%.
Mutagenic activity of the QASs in the Amestest with histidine-dependent Salmonella typhimurium TA98 strain. A, 4a; B, 4b; C, 5a; D, 5b; E, 6a; F, 6b; G, 7a; H, 7b. C1 (marked in white), negative (water) control; C2 (marked in black), positive control (2-amino-3
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Graphical Abstract
Scheme 1:
Reagents and conditions; I: HO(CH2)6Br, BF3·Et2O/CH2Cl2, 1 h 0 °C → 3 h, rt, ([32] compound 2 36% yield...